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Pepto-Bismol, which contains bismuth subsalicylate, undergoes minimal metabolism in the body. Bismuth is mostly excreted unchanged in the feces, while salicylate, a component of the compound, is absorbed and metabolized in the liver. Salicylate can be conjugated to form various metabolites, including salicyluric acid, which are then excreted in the urine. Overall, the primary mechanism of action is local, providing relief in the gastrointestinal tract rather than systemic metabolism.

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1w ago

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