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Benadryl (Diphenhydramine HCl) is metabolized in the liver, although it is distributed throughout the body (including the central nervous system) and a small amount of it passes unmetabolized in the urine.

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Is Benadryl processed by liver?

Yes, Benadryl (diphenhydramine) is processed by the liver. After oral administration, it undergoes metabolism primarily in the liver, where enzymes convert it into various metabolites. These metabolites are then excreted by the kidneys. Therefore, liver function can affect how the drug is metabolized and eliminated from the body.


Is benadryl affected by 1st pass effect?

Yes, Benadryl (diphenhydramine) is affected by the first-pass effect. When taken orally, a portion of the drug is metabolized by the liver before it enters the systemic circulation, which can reduce its overall bioavailability. This means that the amount of active drug that reaches the bloodstream and exerts its effects may be less than the total dose taken. However, the clinical effects of Benadryl are still typically significant despite this metabolic process.


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