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The amount of time it takes for the amount of drug in the body to reduce by 50% is called the half-life. It takes approximately five to six half lives for the drug to be cleared from the body. The half-life for fentanyl patches is 9.5 to 12.4 hours. Multiply that by 6 and it could take up to 74.4 hours to clear the drug. You can do the math. Fentanyl lozenges-approx. 7 hours.

Duragesic takes a few hours to kick in and is supposed to last up to 72 hours (like how Oxycontin is supposed to last 12 hours) but most people find it lasts 36-60 hours. From my experience I've found fentanyl patches to last about 48-54 hours. In regards to drug testing, assuming it's a UA, fentanyl takes longer to clear than most opiates, it would take AT LEAST 48 hours after the removal of the patch (assuming you wore it for at least 2 days)

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