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The average for most people is about 3-5 hours before you start feeling heavier withdrawals. After that, the discomfort gets worse, especially if you're not used to dealing with it, or you don't have any breakthrough meds to help compensate for the decrease in Fentanyl from your system.

At that point, the withdrawal pain starts to become as bad or worse than the pain you're using the patches for in the first place. That's why it's important to time your patch replacement so that you're adding a new one while the old one is winding down, so you have some overlap and steady dosage rate.

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14y ago

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