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Depends on the pill form, the way it's administered, and the medicine. At the low end, nitroglycerine tablets, administered sublingually (under the tongue) hit the bloodstream in under 1 minute. Most uncoated tablets will start entering the bloodstream in 30 minutes to an hour after oral injestion, with coated tablets taking a little longer. However, you may not reach Cmax -- the point of maximum (and desired) concentration in the plasma for weeks in some medications.

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