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Robitussin-AC, is a prescription antitussive containing Guaifenesin and Codeine.

5 mL of Robitussin-AC contains 100 mg of Guaifenesin, an expectorant 10 mg of Codeine, a cough suppressant. A normal dose of Robitussin-AC is 5-10 mL every 4-6hrs.

Oxycodone (Percocet, Percodan, OxyIR, OxyContin) is a significantly different drug compared to codeine despite their chemical similarities. Oxycodone is semi-synthetic opioid partially derived from Codeine, a naturally occurring opiate alkaloid found in opium poppy. Oxycodone is a far more potent opioid commonly used for postoperative and chronic pain. Approximately 10 mg of oral Codeine is equivalent to 1 mg of oral Oxycodone.

Codeine is a more effective antitussive than oxycodone thus codeine is commonly used in cough medications and for mild pain.

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