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Prednisone, which is a steroid, is commonly used by vets in treating a number of skin disorders, including hot spots. But only administer it to your dog if your vet has instructed you to do so. If you aren't sure if it is a hot spot, then the dog needs to be examined in order to be properly diagnosed and treated. Also, give this medication exactly as prescribed by your vet. The dosage of this med is gradually decreased over the course of the treatment. To give your dog this med, and then stop giving it abruptly, without decreasing the dosage gradually, can cause serious health risks for the dog.

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