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Tricyclics are more potent antidepressants compared to the newer SSRIs. The reason SSRIs tend to be prescribed more, however, is because tricyclics are less well tolerated due to their antimuscarinic effects, such as: dryness of mouth, constipation, dizziness, abnormal heart rhythm, blurred vision and urinary retention. Trycyclics cannot be given to people with with hypotension or heart problems. SSRIs generally have a longer half life (15-50 hrs vs. 12-32 hrs for trycyclics) and do not require as high a concentration in the blood as tricyclics for their therapeutic effect.

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