Acetylcholine Inhibitors...
That would include organophosphates, curare (or tubocuranine), succinylcholine, (a flaccid paralytic used in anesthesia to relax striated muscles for intubation), and various neurotoxins.
ACh will decrease heart rate/contractile strength, etc. Atropine is a muscarinic ACh receptor (mAChR) antagonist, so blocks the effects of ACh. Adding both together will result in a weak action of ACh that tails off as all the mAChRs become blocked by Atropine.
it is an alpha-toxin that binds to acetylcholine binding sites on the postsynaptic cell membrane, which prevents the acetylcholine from acting. Curare blocks synaptic transmission by preventing neural impulses to flow from neuron to neuron. It does allow the action potential to travel in the axon, it just doesn't pass it on to the dendrite.
Scopolamine is an anticholinergic drug, meaning it blocks the action of acetylcholine at muscarinic receptors in the nervous system. As a result, it does not produce a cholinergic response; instead, it inhibits functions typically mediated by acetylcholine, such as salivation and gastrointestinal motility. It is commonly used to prevent motion sickness and nausea.
acetylcholine
A common chemical that prevents continuous muscle stimulation is acetylcholine esterase inhibitor. This type of inhibitor blocks the action of acetylcholine esterase, the enzyme responsible for breaking down acetylcholine in the synaptic cleft. By inhibiting this enzyme, acetylcholine accumulates, preventing the muscle from receiving continuous stimulation and leading to muscle relaxation. Examples of such inhibitors include drugs like neostigmine, which are used in certain medical conditions.
Atropine does not only block nicotinic receptors but also acetylcholine at muscarinic receptors
The blocking of GABA release will cause convulsions, where as the blocking of acetylcholine will cause paralysis.
is the release of acetylcholine from the motor neuron into the synaptic cleft.
myasthenia gravis
Alpha-Motor neurons release the neurotransmitter acetylcholine at a synapse called the neuromuscular junction. When the acetylcholine binds to acetylcholine receptors on the muscle fiber, an action potential is propagated along the muscle fiber in both directions.
Atropine is an agent that blocks parasympathetic nerve impulses by inhibiting the action of acetylcholine at muscarinic receptors. It is commonly used in medical settings to increase heart rate and dilate the pupils.
Acetylcholine is broken down by the enzyme acetylcholinesterase into acetate and choline. This breakdown process is essential for terminating the action of acetylcholine at the synapse, allowing for proper signaling between nerve cells. Excess acetylcholine breakdown can lead to conditions such as myasthenia gravis.