An IgG4 test measures the level of immunoglobulin G4 (IgG4) antibodies in the blood, which are part of the immune system's response to allergens and certain diseases. Elevated IgG4 levels can be associated with conditions such as IgG4-related disease, a type of autoimmune disorder, as well as Allergies and certain infections. The test is often used to help diagnose or monitor these conditions. However, interpreting IgG4 levels requires a comprehensive evaluation by a healthcare professional.
A high IgG4 level typically indicates an increased immune response, often associated with chronic allergic reactions or certain autoimmune conditions. Elevated IgG4 can also be seen in specific diseases, such as IgG4-related disease, which is characterized by inflammation and damage to various organs. However, high IgG4 levels can sometimes be found in healthy individuals, so the context of the level, along with clinical symptoms, is crucial for interpretation. It is important to consult a healthcare professional for an accurate diagnosis and understanding of IgG4 levels.
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The smallest molecular weight immunoglobulin is IgG, specifically the IgG4 subclass. This immunoglobulin isotype is the smallest in size among the IgG subclasses, weighing approximately 150 kDa.
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Elevated IgG4 levels will sometimes point to allergic diseases, asthma and cystic fibrosis. Without knowing more about other lab results, it is impossible to discern a specific problem just from an elevated IgG level. Some people also just tend to have normal levels on the outlying edges of laboratory normal.
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