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Renin can be upregulated in two ways:

Macula densa cells in the early distal tubule of the nephron communicates with the juxtaglomerular cells of the afferent arteriole in the kidney. When the macula densa cells detect low levels of sodium, it will communicate that to the juxtaglomerular cells and in turn that will stimulate the production of renin. This is the glomerular tubular feedback system.

The second way it can be stimulated is by the somatic nervous system directly. When the baroreceptors detect a drop in pressure they will stimulate your SNS and inhibit your PNS. This has several cardiovascular effects in addition to stimulating renal nerves that will upregulate more renin from the juxtaglomerular cells.

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14y ago

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