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Aspirin is a non-selective and irreversible inhibitor of a class of enzymes known as COX. These enzymes are responsible for the production of prostaglandins and thromboxane. There are several subtypes of prostaglandins, some of which induce bronchospasm (PGE2) and others that cause bronchodilation (PGI2). But this is unimportant since aspirin will block the production of all prostaglandins.
If you look at the figure below, you can see that COX enzymes are only half of the story in the metabolism of Arachidonic acid. The other half is known as the Lipoxygenase (LOX) pathway
This LOX pathway is responsible for the production of pro-inflammatory chemicals known as Leukotrienes (LTs). By blockade of the COX pathways, all of the arachidonic acid is funneled into the LOX pathway, thereby increasing these pro-inflammatory chemicals. And since pro-inflammatory chemicals are the same chemicals that produce Allergies and anaphylaxis --> Bronchoconstriction occurs.
In other words, by blocking the synthesis of PGs (some of which can bronchodilate), the balance between bronchodilators and bronchoconstrictors is deregulated, leading to a predominance of bronchoconstrictors, hence the Asthma.
What else can I help you with?
Does aspirin help chronic obstructive pulmonary disease?
no may be because aspirin can cause bronchospasm so make the copd worst
Can toprol cause you to cough?
Yes. This drug can cause you to cough. This is contraindicated in asthma. It can cause bronchospasm in some individuals.
What disease can Aspirin cause?
Aspirin can cause Reye's syndrome
What is paradoxical bronchospasm?
i have the paradoxical bronchospasm
Which general anaesthesia is contraindicated in asthmatic patients?
desflurane (because it can cause respiratory infection - cough, bronchospasm)
Can aspirin cause misc?
no
Why is bronchospasm contraindicated for suctioning?
Bronchospasm is contraindicated because the suction tubing when it comes into contact with the airway walls can cause further contraction of the airways and reduce the patients ability to breath more that the effect the mucus that the suctioning is trying to clear.
Does aspirin cause constipation?
aspirin alone may not causes constipation aspirin combine with codeine or caffeine causes constipation
Does aspirin cause water retention?
No
Can aspirin cause jaundice?
yes it can
Does cortal 500mg is effective to cause miscarriage?
No, Cortal is Aspirin and does not abort.
Is bronchospasm curable?
Bronchospasm is not necessarily curable, but it can be managed and treated effectively with medications such as bronchodilators and corticosteroids. Lifestyle changes, such as avoiding triggers like smoke or allergens, can also help reduce the frequency and severity of bronchospasm episodes. It is important for individuals with bronchospasm to work closely with their healthcare provider to develop a treatment plan that works best for them.
