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John C. Calhoun's arguments for nullification centered on the idea that states have the right to invalidate Federal Laws they deem unconstitutional. He believed that the federal government was a creation of the states, and thus, states maintained ultimate sovereignty. Calhoun argued that if the federal government overstepped its bounds, states could protect their rights and interests by nullifying such laws. This doctrine was rooted in the principle of states' rights and was a response to perceived federal overreach, particularly regarding tariffs and economic policies.

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