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In 1347 a Genoese ship from Caffa, on the Black Sea, came ashore at Messina, Sicily. The crew of the ship, what few were left alive, carried with them a deadly cargo, a disease so virulent that it could kill in a matter of hours. It is thought that the disease originated in the Far East, and was spread along major trade routes to Caffa, where Genoa had an established trading post. When it became clear that ships from the East carried the plague, Messina closed its port.

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