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In the late 1400s, European explorers and colonizers encountered various Indigenous tribes across the Americas. In North America, they faced tribes such as the Taino in the Caribbean, the Powhatan Confederacy in Virginia, and the Iroquois in the Northeast. In Central and South America, they encountered sophisticated civilizations like the Aztecs and the Incas. These interactions often led to conflict, disease, and significant cultural changes for the Indigenous peoples.

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