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Mesopotamia is a place, not a civilization. There have been numerous civilizations in Mesopotamia which have met their own downfalls for very different reasons ranging from over-expansion, to invasion, to internal strife, to food shortages.

Mesopotamia as a region became less relevant as the center of civilization shifted towards Europe and the region as a whole became less fertile. (This was offset between 800-1200 C.E. when Baghdad became one of the foremost cities in the world.)

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