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The most significant proponent of the nullification doctrine was John C. Calhoun, a prominent American politician and statesman from South Carolina. He argued that states had the right to nullify Federal Laws they deemed unconstitutional, asserting that the Constitution was a compact among sovereign states. Calhoun's ideas were most famously articulated in response to the Tariff of Abominations in the early 1830s, leading to the Nullification Crisis, which highlighted tensions between federal authority and states' rights.

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