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Rome gained indirect control over western and central Anatolia in 188 B.C., after her victory against the Seleucid Empire in the Roman-Seleucid War (also known as the War of Antiochus, 192-188 B.C.). The Romans were supported by their allied Greek states, Pergamon and Rhodes and with non-military support by the Achaean league and Macedon (also Greek states). Rome won the Battle of Thermopylae in Greece) and, together with Pergamon, in 191 B.C. and the Battle of Magnesia (near present day Manisa and Izmir, on Turkeys western coast) in 190 B.C. Rome and Rhodes won two naval battles, both in 190 B.C. With the treaty of Apamea of 188 B.C., Rome gave Caria and Lycia (on the coastal area of south-western Turkey) to Rhodes. She gave Mysia, Phrygia, Pisidia and Lydia (inland in western Anatolia), Pamphylia (on the southern coast) Phrygia and Lycaonia (in central Turkey) to Pergamon. In 189 B.C. the consul Gnaeus Manlius Vulso, aided by Pergamon, conducted a campaign against Galatia, in central Anatolia. The Galatians were defeated and sued for peace and Galatia became a Roman ally. Vulso acted without the consent of the senate and justified his actions by presenting it as retaliation for the Galatians fighting alongside the Seleucids during the war. He was reproached for not consulting the senate and was accused of endangering peace with the Seleucids. Cappadocia, also in central Anatolia, switched their alliance from the Seleucids to Rome. In

168 B.C. Rome separated the Lycian League (a federation of Lycian cities) from Rome and granted self-rule because of mistreatment by Rhodes.

In 133 B.C. Attalus III, the king of Pergamon died and bequeathed his kingdom to the Romans. The kingdom of Pergamon became the Roman province of Asia. In 74 B.C. Nicomedes IV, the king of Bithynia bequeathed his kingdom to Rome. In 73-63 B.C. the Romans fought the Third Mithridatic War against Mithridates VI of Pontus and Tigranes the Great of Armenia. The Romans won the war and annexed the western part of Pontus to Bithynia, which became the Roman province of Bithynia et Pontus. It covered the western and central part of the northern coast of Anatolia.

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