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The Cherokee tribe suffered the most economically during the removals, particularly during the Trail of Tears in the 1830s. Forced to leave their ancestral lands in the Southeast U.S., they lost not only their homes but also their agricultural economy and resources, leading to widespread poverty and hardship. The economic disruption was compounded by the loss of livestock, crops, and the social structures that supported their community. This devastation had long-lasting effects on their economic stability and development.

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