Deaths at Little Bighorn included 268 men of the US 7th Cavalry Regiment including it's Commander, Lt. Col. George Armstrong Custer, and the complete annihilation of the battalion sized force directly under his command that day, and anywhere between 36 and 300 Lakota and Northern Cheyenne warriors.
Some reports also disclose an unknown number of women and children killed by Major Reno's initial volleys into the camp. Reno himself, a Survivor of the action, acknowledges this but was unable to give a realistic estimate of deaths.
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Lt. Col. George Custer.
The Battle of Little Big Horn
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The significance of the Battle of Little Big Horn was that it was the last major Native American victory due to the government stepping up military action.
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