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There were several Greek victories over Persia over 150 years.

The culminating one of Alexander's total defeat and taking over of the Persian Empire had several results:

  1. His successors (generals) carved up his conquests and established kingdoms and dynasties of their own, of which the most durable were Macedon, Syria and Egypt, known as the Hellenistic kingdoms.
  2. These dynasts superimposed a veneer of Hellenistic organisation and culture in the Middle East, with a modicum of civilising effects.
  3. They engaged in warfare with each other, tussling for territory, so the stability of the kingdoms was offset by the competition between them. Persian rule had been benevolent, and there isn't much reason to believe that the Greek kingdoms improved on the Persian one.
  4. When Rome expanded its empire to the Greek east, these kingdoms slotted into the empire.
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