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Antioch was the third largest city in the Roman Empire.

Antioch was certainly the third largest city in the Byzantine empire after Constantinople and Alexandria. Hoverer, the situation in the classical period of the Roman Empire is not sure. Rome and Alexandria were the two largest cities. The third largest one may have been one of these cities; Antioch, Ephesus or Carthage. These cities have a similar population estimate of 300,000-50O,000.

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