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The word 'mistletoe' is of uncertain etymology; it may be related to German Mist, for dung and Tang for branch, since mistletoe can be spread in the feces of birds moving from tree to tree. However, Old English mistel was also used for basil.

European mistletoe, Viscum album, is generally considered a poisonous plant that causes acute gastrointestinal problems including stomach pain, and diarrhea along with low pulse. However it has a long history of use in (herbal) medicine and has garnered a lot of attention (and studies) for its anti-cancer properties.

The name was originally applied to Viscum album (European Mistletoe, Santalaceae), the only species native in Great Britain and much of Europe. Later the name was further extended to other related species, including Phoradendron serotinum (the Eastern Mistletoe of eastern North America, also Santalaceae).

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