Well, honey, a whole butternut squash typically yields about 4 cups of cubed squash, which is roughly equivalent to 24 ounces. So, if you're looking to swap in pre-cut cubes, you'd need around 24 ounces to match a whole squash. Just remember, cooking ain't an exact science, so don't stress too much about the measurements!
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I just pureed an entire Butternut squash (without the skin) and it filled 26, 1oz ice cube spots. So I would say around 24-26 ounces or more if you did the skin too.
A large butternut squash baked and flesh scooped out equals between 2 1/2 to 3 cups (I do this for my butternut squash bisque/soup).