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In fact, when the Queens son, Leopold, Duke of Albany was diagnosed with hemophilia in 1848, the Queen quite indignantly stated "this disease is not [in our family"]. She was of course right however as in the Queen and Prince Leopold it did indeed appear to be a spontaneous mutation. Although it is believed by modern science that the gene had lain dormant and was passed to her through her Hanoverian ancestors. Her daughter, Princess Alice passed the defective gene on to her female offspring This "spontaneous mutuation" would play a significant role in European politics up to 1918. She didn't actually have the disease herself, but was a genetic carrier for the condition hemophilia, where your blood does not have the enzyme that enables blood to clot. In this way, she passed it to most of the royal houses of Europe, as her children married into them. Interestingly, she always thought it came through her husband but it is now known to have been passed through her.

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