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The federal agency responsible for regulating the interstate shipment of hazardous materials (hazmat) is the Pipeline and Hazardous Materials Safety Administration (PHMSA), which operates under the U.S. Department of Transportation (DOT). PHMSA establishes and enforces regulations for the safe transport of hazardous materials by various modes, including road, rail, air, and water. Their regulations aim to protect people, property, and the environment from the risks associated with hazmat transportation.

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