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The non-essential subordinate clause is marked off by two commas, which act as a pair of parentheses.

'My cousin is a doctor' (independent clause).

'My cousin, who lives in Manchester, is a doctor' (non-essential subordinate clause; the information 'who lives in Manchester' is merely descriptive).

'My cousin who lives in Manchester is a doctor' (essential subordinate clause; the information 'who lives in Manchester' distinguishes this cousin from my other cousins who live elsewhere, therefore there are no commas).

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