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1) nicotinic acetyle choline receptors are ligand gated ion channels, where as mucarinic Ach receptors are G-proteins coupled receptors system.

2) nicotine is a agonist/ muscarine( a toxin produced by certain mushrooms) is a agonist.

3) action of nicotine is fast(1-2msec)/action of muscarinic is slow (100-250msec).

4) in case of nicotinic ach receptor, subtypes based on different subunit composition.muscle and neuronal classification/in case of muscarinic receptor at least 5 receptors subtype have been described by molecular cloning.

5) in case of nicotinic receptor agonist effects blocked by tubocuranine/in case of muscarinic receptor agonist effects blocked by atropine.

6) nicotinic receptor found at neuro muscular junction of skeletal muscle, on the post ganglion neurons of the parasympathetic nervous system and on many neurons on the brain(hypothalamus)/muscarinc receptor found at neuromuscular junction of cardiac and smooth muscle as well as on glands and on the post ganglionic neurons of the sympathetic nervous system.

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