If you are running through scummVM (which you probably are), press F5 to bring up the save menu.
If you are playing through another engine, F1 or Escape are also possible.
If you are playing on Sega CD then there is no save function, and you must rely on the passwords given at checkpoints.
Hit esape & save game
You X out of it and it will be saved.
The Secret Rank is after you save Scizor from Blizzard Island. This allows you to take legendary Wonder Mails.
save scizor from blizzard island
save scizor from blizzard island because he is with the Pokemon federation
The game should automatically save everything...
The game saves by itself.
Near the junk yard
To save your game in Dog Island, you need to find a "save point" represented by a doghouse. Walk up to the doghouse, interact with it, and select the option to save your game. Make sure to save regularly so you don't lose your progress!
in your house there is a black phone stand in front of it and tap it then you can save your game you can also just press the start button then click save
In "Spy Island" at the end of the game to save the 3rd spy.
Monkey Island 4 is particularly buggy on newer systems. It is highly recommended that you download the EMI launcher from mixnmojo. That will clear up a lot of the issues, but it will still freeze/crash sometimes during the pirate or monkey fights. It's really just a case of save frequently and hope it doesn't at the moment.