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Guinea pigs frequently have litters ranging in size from 1 to 6 pups. When a particularly young female is impregnated it is more likely she will have a small litter. Of course, a guinea pig that delivers only one pup should be monitored closely and taken to a vet if she shows signs of discomfort, restlessness, labored breathing, etc. Complications can occur during labor due to the relatively large size of guinea pig pups.

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