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If you are looking for any dog that has the least risk of congenital, developmental or inherited diseases, your best bet is to get the most hybridized cross-bred mutt you can find - your goal should be a dog that even a veterinarian or a shelter worker can't figure out what breeds went into that dog. Every pedigree breed has a list of diseases that members of that pure breed are more likely to get or are more likely to develop. By getting a cross-breed, and preferrably a third generation or further multiple-breed cross-breed or mutt, you reduce the risk of the genes associated with disease from any one breed will be dominant enough to actually cause the disease.

However, this is a probability statement, not a guarantee of risk absence - all dogs, regardless of pedigree and breed background, will have some inherited predispositions to disease that can either be managed or be neglected. Also, dogs are susceptible to a wide variety of Infectious Diseases as well as acquired diseases like Diabetes, which are related to lifestyle.

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