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Both of these medications are generally safe, and are not often associated with acute toxicity. The LD50 for both is astronomical, and that's only 50%.

Lisinopril is usually dosed at 30-40mg once a day, with rare dosages going as high as 80mg. Hydrochlorothiazide is dosed at 25-50mg once daily. In combination, the starting dosage of either or both probably will be considerably lower, as these medications interact.

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Does lisinopril 25 mg HCTZ 20mg cause weight gain?

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