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Why is levodopa and carbidopa given together?
Levodopa and carbidopa are given together to enhance the effectiveness of Parkinson's disease treatment. Levodopa is converted to dopamine in the brain, alleviating symptoms, but it can also be metabolized peripherally, leading to side effects. Carbidopa inhibits the enzyme that breaks down levodopa outside the brain, allowing more levodopa to reach the brain and reducing side effects like nausea and vomiting. This combination improves the overall efficacy of the therapy.
Why does vomiting relieve migraine pain?
it cures it
What are the side effects of levodopa?
Anorexia, loss of appetite, occurs in roughly half the patients using this drug. Symptoms of gastrointestinal upset, such as nausea and vomiting, have been reported in 80% of cases.
What will happen if pyridoxine is given with levodopa?
pyridoxine (vitamin B6) can decrease the effect of levodopa.
What does carbidopa do?
Levodopa itself is not well tolerated, which is why it is combined with carbidopa. Carbidopa decreases peripheral metabolism of levodopa, which allows for lower doses of levodopa and less-severe side effects.
How to avoid giving levodopa in high dose to Parkinson's patients?
Although levodopa can cross our BBB, but it will be decarboxylated to dopamine peripherally before reaching our CNS - only small amount of Levodopa will be left and available to pass our BBB.So, instead of giving levodopa in high dose (which can cause lots of side effects), we give levodopa with peripheral decarboxylase inhibitors (e.g. carbidopa, benserazide) which can inhibit decarboxylation of levodopa in GIT and peripheral tissues. (By combining levodopa and peripheral decarobxylase inhibitors, we will have less side effects too)
Can vomiting be a sign of a heart attack?
Vomiting will not necessarily relieve the pain caused by a heart attack. The best thing to do if you suspect of having a heart attack is to take an aspirin and call emergency services (911 in USA, 999 in the UK).
How can you relieve bloating caused by water retention?
pee
How do you treat vomiting caused by a concussion?
get to hospital asap
What is l dopa?
levodopa
Can vomiting cause rectal bleeding?
Could happen if caused serious injuries...
What causes Russell's sign?
It is caused by self-induced vomiting
