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Action potentials arise when a neuron's membrane potential reaches a threshold, typically due to depolarization caused by the influx of sodium ions (Na+) through voltage-gated sodium channels. This rapid change in membrane potential leads to a positive feedback loop, where more sodium channels open, causing further depolarization. Once the peak is reached, potassium channels open, allowing potassium ions (K+) to exit the cell, leading to repolarization. The process restores the resting membrane potential, completing the action potential cycle.

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Postsynaptic potentials are changes in the membrane potential of the postsynaptic terminal of a chemical synapse. Graded potentials are changes in membrane potential that vary in size, as opposed to being all-or-none, and are not postsynaptic potentials.


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Action potentials are rapid, temporary changes in the electrical membrane potential of neurons and muscle cells that allow for the transmission of signals. They occur when a cell depolarizes to a certain threshold, leading to a wave of electrical activity that propagates along the cell membrane. Action potentials are crucial for communication within the nervous system, as they facilitate the transmission of information between neurons and the activation of muscles, thus playing a vital role in coordinating bodily functions and responses.


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Graded potentials are local potentials that vary in magnitude according to the strength of the stimulus. They can either be depolarizing or hyperpolarizing and play a role in generating action potentials in neurons. Graded potentials are responsible for the integration of multiple signals in the nervous system.


What are pacemaker potentials and the action potential they trigger?

Pacemaker potentials are automatic potentials generated and are exclusively seen in the heart. They arise from the natural "leakiness" of the membrane that pacemaker cells have, resulting in passive movement of both Na+ and Ca2+ across the membrane, rising the membrane potential to about -40mV. This results in a spontaneous depolarization of the muscle that has a rise in the curve that is nowhere near as steep as the action potential of other cells. Upon depolarization, the cell will return back to its resting membrane voltage, and continue the potential again.


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Postsynaptic potentials can be inhibitory as well. Inhibitory postsynaptic potentials (IPSPs) hyperpolarize the postsynaptic neuron, making it less likely to generate an action potential.


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Standard electrode potentials are listed in the table in decreasing order, with the strongest reducing agents (highest standard reduction potentials) at the top and the strongest oxidizing agents (lowest standard reduction potentials) at the bottom. The potentials are measured relative to the standard hydrogen electrode.