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The best driving route from Charlotte, NC to Gainesville, VA typically involves taking I-77 N to I-81 N, then merging onto I-66 E. This route offers a balance of speed and scenic views as you travel through the Appalachian region. The total distance is approximately 300 miles, and the drive usually takes about 4.5 to 5 hours, depending on traffic and road conditions. Always check for real-time traffic updates before your trip for the best experience.

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2w ago

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