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He's not dead, so no one killed him.

If you're referring to the previous timeline seen in the episode Life of Brian, the answer is still no one killed him. Meaning the person that was driving the car was not relevant to the story so they were not shown, it was just a speeding car.

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10y ago
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10y ago

He was run over and killed by a car in Life of Brian & Stewie altered the time line and saved him in Christmas Guy.

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Q: Who killed Brian Griffin?
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