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The first nations people by and large were nomadic and did not live in large urban conurbations. They also did not have domesticated animals. This meant that their environment did not produce plague diseases (apart from syphilis) and therefore the native people were not immune to or regularly exposed to plague diseases.

The situation in the Old world was different, there were large urban conurbations and livestock lived in close proximity to people resulting in people being regularly exposed to epidemic organisms (which were crossing the species barriers) but surviving these.

When the two people came in contact the new world people succumbed rapidly to the infection the old world brought with them (because they had no immunity) and 90-95% of these people died.

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Q: Why did epidemics affect the first nations people?
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