What is the alternative of protamine?

Answer 1

The alternative to protamine for reversing the effects of heparin is the use of a specific antidote called andexanet alfa, which is primarily used for reversing anticoagulants like factor Xa inhibitors. Another option is the use of other agents such as recombinant activated factor VII (eptacog alfa) in certain situations, though these are not direct replacements for protamine. Additionally, in some cases, mechanical methods such as dialysis may be employed to remove heparin from circulation. However, the choice of alternative depends on the specific clinical scenario and the type of anticoagulant used.