Yes. When substances are lipophilic (hydrophobic), they are usually much more easily retained in fat in the body, reducing its elimination rate. This allows for such substances (such as lipophilic vitamins) to accumulate in the body to toxic levels.
The COOH group can be changed to a tetrazole group to increase the drug's lipophilicity. Both groups have a similar pKa value so the ionisation of the molecules should be similar.
Chemical: Toxicity is about a harmful material interacting chemically with other substances in the body.
Toxicity is a chemical property. You can not see the toxicity just by looking at it.
Selective toxicity
Toxicity refers to the degree to which a substance can harm living organisms. It can disrupt biological functions, damage cells, and lead to illness or death depending on the type and amount of exposure. Toxicity assessments are important for determining safe levels of exposure to a substance.
The COOH group can be changed to a tetrazole group to increase the drug's lipophilicity. Both groups have a similar pKa value so the ionisation of the molecules should be similar.
May increase toxicity of other cardioactive drugs. Not to be used with diuretics, amphetamines, medication for respiratory problems. And more . . .
Pulmonary Oxygen Toxicity (PO) and Central Nervous System Toxicity (CNS)
An increase in oxygen levels can lead to hyperoxia, causing symptoms like respiratory problems, disorientation, and in severe cases, oxygen toxicity which can damage organs. In certain conditions like scuba diving, high oxygen levels can result in central nervous system toxicity. It is essential to maintain a balance of oxygen in the environment for the well-being of living organisms.
Toxicity label was created in 1971.
Toxicity - song - was created in 2001-03.
Chemical: Toxicity is about a harmful material interacting chemically with other substances in the body.
Toxicity can be both qualitative and quantitative. Qualitative toxicity refers to the presence or absence of harmful effects, while quantitative toxicity involves measuring the degree or severity of the toxic effects. Factors such as dose, exposure duration, and individual susceptibility can influence the quantitative assessment of toxicity.
Asthma patients using theophylline may increase the amount of theophylline absorbed, perhaps leading to toxicity. Consult with a medical practitioner.
Toxicity - Hazardous to living organismsIf you own something that has any level of toxicity, immediately dispose or destroy it.
By dumping industrial wastewater into fresh and saltwater sources, we hope to increase the mercury content of the fish to a high enough toxicity that they will no longer be suitable for human consumption. As the fish become more contaminated the demand for fish as food will decrease which will dramatically increase the population of salmon.
Abnormally slow breathing is a symptom of oxygen toxicity