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SSRIs works by reuptake inhibition- leaving more serotonin in the synapse. It has been raised that this also implies lowering dopamine.
Many patients report typical "dopamine" side-effects with longterm chronic use of SSRIs. Apathy, anhedonia, hyperprolactinemia, extrapyramidal symptoms, sexual and cognitive dysfunction, galactorrhea, mammary hypertrophy, and gynecomastia.
Studies do show that SSRI effect dopamine. SSRI "hijack" dopamine signaling as well launching serotonin signals causing the brain to produce less dopamine.
The second thing to consider is that because SSRIs work to increase synaptic levels of serotonin, this means that where 5-HT terminals interact with dopamine terminals, directly or indirectly via GABAergic interneurons, as they do the frontal cortex for example, SSRIs have an indirect effect on dopaminergic transmission, where they are thought to increase dopamine release.
The third and final point to remember is that dopamine terminals wont just be receiving 5-HT or GABA input - they will be under the influence of other neurotransmitter systems, from lots of different areas of the brain - which makes their firing very tightly buffered against changes in serotonin caused by SSRIs. This is why there is a lot of conflicting evidence on how dopaminergic transmission may be altered via manipulations to the serotonergic system.
Pharmacology isn't without its irony.
What else can I help you with?
What increases dopamine in the brain?
The supplement 5-hydroxytryptophan (5-HTP) is a substance your body creates from an amino acid called tryptophan. 5-HTP, in turn, is used to create serotoninUnlike serotonin itself, 5-HTP can readily make its way from your bloodstream to your brain, where it can quickly be converted into serotonin.5-HTP does not convert, but influences the release of dopamine and norepinesphrine.Tyrosine is an amino acid ingested through protein foods. It is converted into the neurotransmitters dopamine and norephinephrine.Carbohydrates from fruits, vegetables, whole grains and cereal raise levels of tryptophan, an amino acid the body needs to make serotoninVitamin B6 works to bring neurotransmitters in balanceIncrease Omega-3 - fatty acids (DHA and EPA) found in fish (salmon, herring, mackerel, tuna) obtained only through diet increase serotoninReduce intake of Omega-6 (found in vegetable oils, meat, milk, eggs, soybean, corn oils) In recent times, omega-6 have increased in individuals to 10 - 25 times more than the amount needed in the diet.Balance the ratio of Omega 6 to Omega 3Vitamin pills and mineral supplements cannot replace nutrition found in real foods from other contributors:There is no relationship of Tyrosine to Serotonin, it is not involved in the Serotonin synthesis; 5-HTP is also a precursor to serotonin.Insulin surges, low blood sugar and anemia effect the production of the brain's ability to produce both these NT's.MAO inhibitors are not the first line of meds for depression and have many adverse reactions and effects ( side effects are just effects). Those taking drugs which are MAOI's need to be aware of the chance of having a medical hypertensive emergency reaction between them and high Tyramine foods like aged, smoked , pickeled , spoiled, cured , fermented or smoked foods and certain drugs, etc.Dopamine can be made from Tyrosine but Tyrosine is not an essential amino acid. But is essential to the brain as the brain cannot make it and needs the liver to produce it from the essential amino acid DLPAThere is a need to balance low or high blood sugar in order to allow the brain to receive the Tyrosine and Anemia must be also corrected in order for proper conversion of Tyrosine to L Dopa which then converts to Dopamine providing there is enough vitamin B 6. Vitamin B 6 is used up often in chronic use of SSRI's like Prozac or alcoholism.. Liver Disease and gut infections also effect the production of dopamine in the brain.The most important way to inactivate used dopamine is reuptake but this is hindered by a lack of Magnesium or Methyl donors. The following use up the Methyl donors needed to recycle dopamine: Hypothyroidism, Low HCl in the stomach caused by H Pylori or other causes, use of Birth control pills, antacids, estrogen replacement therapy to name a few. H Pylori conditions may be supported with H PLR from Apex also.
Are SSRI enzyme inducers or inhibitors?
The SSRIs can be both CYP450 enzyme inhibitors AND inducers. Inhibitors inhibit the metabolism of drugs, causing the body to have increased levels of that drug. Inducers speed of the metabolism of a drug, causing the body to inactivate/eliminate to a further extent than it normally would. It depends on which SSRI you are talking about. They all have actions on various isoforms of CYP450, but the SSRIs which cause the greatest problems with inhibition/inducing are fluoxetine (Prozac) and paroxetine. (Paxil)
How is multiple chemical sensitivity treated by doctors?
Diagnosis and Treatment: There are no reliable tests to diagnose multiple chemical sensitivity and there are no effective or proven treatments. Some doctors prescribe antidepressants, including SSRI (Selective Serotonin Reuptake Inhibitors) like Celexa, Prozac, Paxil.
What is the strongest ssri?
If you are referring to the efficacy as anti-depressants, there is no definitive answer, each manufacturer studies shows their product to be superior to competitors. It is believed that Escitalopram (US: Lexapro, EU: Cipralex) and Paroxetine (US: Paxil, EU: Seroxat) are very powerful. If you are referring to receptor binding potency, then studies in rats show that the strongest SSRIs are Paroxetine and Sertraline. http://www.preskorn.com/books/ssri_s3.html
Why if I took ambien cr for the first time last night was I wide awake 2 hours later any thoughts?
You might have experienced what's called a paradoxical reaction. This is (relatively) common amongst people who have ingested benzodiazapines (alprazolam, diazepam, although these are anxiolytic not hypnotic drugs like ambien) or 'z'-drugs. The desired effect of sedation is usually replaced by excitatory feelings such as loss of inhibition, restlessness and mild euphoria. This is probably due to the effect of GABA binding to BZ receptors in the brain. Changing the dosage may help. Also take into account confounding factors including any other prescription medications you might be taking: ssri's (prozac), weight-loss drugs (xenical, reductil), sndri's (wellbutrin/zyban), besides caffeine (long half-life), alcohol or nicotine.
Is Paxil a dopamine antagonist?
No, Paxil (paroxetine) is not a dopamine antagonist. It is primarily a selective serotonin reuptake inhibitor (SSRI) used to treat depression and anxiety disorders by increasing serotonin levels in the brain. While it may have some effects on other neurotransmitter systems, its main action is on serotonin, not dopamine.
Is Vyvanse a SSRI?
No. Vyvanse is the brand name for lisexamfetamine which is a prodrug of amphetamine. Vyvanse is created in a way that it is not possible to inject or snort the drug to produce a high which makes it less abusable. Amphetamine works on norepinephrine and dopamine receptors, while SSRI's work on serotonin.
What is the best antidepressant for energy?
The answer to this question is going to vary person by person as antidepressants will have side effects that include somnolence and insomnia in the same sentence. Trazadone is a very sedative SSRI at lower doses and has more antidepressant effects at higher doses. Bupropion is probably one of the better antidepressants for energy because of its actions on dopamine and norepinephrine. HOWEVER, bupriopion has no recreational value. It is a dopamine reuptake inhibitor much like cocaine, amphetamine, and methamphetamine but it WILL NOT induce euphoria or other traditional psychostimulant-like effects. Taking more than the recommended dosage will SIGNIFICANTLY INCREASE RISK OF SEIZURE.
Is lamactil an ssri?
Lamictal (lamotrigine) is not an SSRI. It is an anti-convulsant.
What does buspar treat?
It affects a specific serotonin receptor (5HT1A receptor), and to a lesser extent, dopamine. The purpose of Buspar's action is to decrease anxiety commonly associated with depression, and although Buspar has action on serotonin it is not considered to be an SSRI (Prozac, etc).
Give you a list of SSRI?
http://en.wikipedia.org/wiki/SSRI#List_of_SSRIs
Is celexa a benzodiazepines?
no... celexa is an ssri antidepressant and no relation to benodiazepines
Can an SSRI cause ED?
Yes - it is a very common side effect of SSRI medication.
Is depakote a SSRI?
no
Is Prozac a maoi?
Zoloft is not an MAO inhibitor, but combining it with an MAOI inhibitor, whether prescription or in nutrient form, is not recommended. Adverse reactions have been reported, and the FDA has issued an advisory on this drug combination.
What does SSRI stand for?
SSRI stands for Selective Serotonin Reuptake Inhibitor. A group of anti dipressants SSRI stands for Secure Storage and Retrieval of Information.
Is Xanax an ssri?
Yes
