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Yes, hypercalcemia causes nervous system depression - the opposite of (see below)

According to the Human Anatomy and Physiology Textbook by Marieb, hypocalcemia causes neuron excitation and if severe enough, leads to tetany and then paralysis. this is because both serum calcium and intracellular calcium are increased. The reason hypocalcemia causes neuron excitation (contrary to the above logic) is because a decrease in extracellular calcium concentration increases the neuron membrane's permeability to sodium and allows sodium to easily depolarize the neuron's membrane and cause an action potential. Additionally The membrane threshold becomes refractory to depolarization thus many of the symptoms are related to the loss of cell membrane excitability.

How extracellular calcium controls sodium membrane permeability is another question.

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Related Questions

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