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Gastric chief cells (as opposed to the chief cells present in the parathyroid gland) are the zymogen cells in the stomach that release pepsinogen (a precursor (zymogen) of pepsin). Without stimulation chief cells normally secrete pepsinogen at about 20% of the maximum ability.

ACh (released by nerves) is the most important pathway for gastric chief cell activation.

ACh also stimulates parietal cells, which secrete HCl (stomach acid). The fall in pH causes a reflex which further stimulates chief cells.

Alternatively, acid in the duodenum (the first portion of the small intestine), stimulates release of secretin from S cells of the small and large intestine. Secretin also activates gastric chief cells.

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What is the difference between parietal cells and chief cells?

Parietal cells are stomach cells that produce hydrochloric acid and intrinsic factor, while chief cells secrete pepsinogen, which is later activated into pepsin to help with protein digestion. Parietal cells are involved in acid production, while chief cells assist in protein digestion.


What do chief cells do?

Chief cells secret pepsinogen and gastric lipase. Pepsin, the activated form of pepsinogen, can break down proteins into peptides and gastric lipase can break down trigylcerides into fatty acids and monoglycerides.


What do chief cells in the stomach secret?

The chief cells secret pepsinogen and gastric lipase. The activated form of pepsinogen (i.e. pepsin) can break down proteins into peptides. As for the lipase, it can split trigylcerides into fatty acids and monoglycerides.


What do chief cells secrets?

Chief cells secret pepsinogen and gastric lipase. Pepsin, the activated form of pepsinogen, can break down proteins into peptides and gastric lipase can break down trigylcerides into fatty acids and monoglycerides.


What other cells work with the parietal cell?

Chief cells in the stomach work with parietal cells to produce gastric acid. Chief cells secrete pepsinogen, which is activated by the acid produced by parietal cells to form pepsin, an enzyme that helps break down proteins. Together, parietal and chief cells contribute to the digestive process in the stomach.


Which cells secrete Pepsin?

Chief cells in the stomach secrete pepsinogen, which is then activated to pepsin by hydrochloric acid present in the gastric juice. Pepsin is an enzyme that breaks down proteins into smaller peptides during the process of digestion.


What cells produce pepsinogen and hcl?

Chief cells of the stomach (gastric glands in stomach have chief cells)


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