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Cyclosporine is a compound produced by some members of the fungal kingdom, most notably Tolypocladium niveum.

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What is another name for Cyclosporine?

Another name for Cyclosporine is Sandimmune.


Which two groups are closely related evolutionarily plants and animals plants and fungi fungi and animals?

fungi & animals


What kingdom of organisms is related to fungi?

Animals


Who discovered cyclosporine?

Cyclosporine was discovered by a team of researchers led by Hartmann F. Stähelin and Jean-François Borel in Switzerland in 1970. They were studying soil samples for potential antibiotic properties and identified cyclosporine as a compound produced by the fungus Tolypocladium inflatum.


What drug is Cyclosporine produced from?

Ciclosporin, cyclosporine or cyclosporin is an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system and, so, the risk of organ rejection. Initially isolated from a Norwegian soil sample, Ciclosporin A, the main form of the drug, is a cyclic nonribosomal peptide of 11 amino acids (an undecapeptide) produced by the fungus Beauveria nivea, and contains a single D-amino acid, which are rarely encountered in nature. Cyclosporine A is synthesized by a nonribosomal peptide synthetase, cyclosporine synthetase. The enzyme contains an adenylation domain, a thiolation domain, a condensation domain, and an N-methyltransferase domain. The adenylation domain is responsible for substrate recognition and activation, whereas the thiolation domain covalently binds the adenylated amino acids to phosphopantetheine and the condensation domain elongates the peptide chain. Generic ciclosporin preparations have been marketed under various trade names including Cicloral (Sandoz/Hexal) and Gengraf (Abbott). Numbnuts just get straight to the damn answer the answer is Imperfect Fungi don't read all the useless crap