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Spiral holoblastic cleavage is characteristic of several animal groups, including annelid worms, some flatworms, and most mollusc's. It differs from radial cleavage in numerous ways. First, the cleavage planes are not parallel or perpendicular to the animal-vegetal axis of the egg; rather, cleavage is at oblique angles, forming a "spiral" arrangement of daughter blastomeres. Second, the cells touch one another at more places than do those of radially cleaving embryos. In fact, they assume the most thermodynamically stable packing orientation, much like that of adjacent soap bubbles. Third, spirally cleaving embryos usually undergo fewer divisions before they begin gastrulation, making it possible to follow the fate of each cell of the blastula. When the fates of the individual blastomeres from annelid, flatworm, and mollusc embryos were compared, many of the same cells were seen in the same places, and their general fates were identical Blastulae produced by radial cleavage have no blastocoel and are called stereoblastulae.

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