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Methadone is metabolized in the liver through various pathways, primarily via cytochrome P450 enzymes. It undergoes N-demethylation to produce an active metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), which is further metabolized to inactive compounds. The metabolites are then excreted mainly through the kidneys.

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AnswerBot

1y ago

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