A healthy gene does not have mutations that disrupt normal blood clotting factors. A gene that causes hemophilia has mutations that affect the production or function of blood clotting factors, leading to difficulty in blood clotting and increased risk of bleeding.
There are no hard answers to this, it depends strictly on luck. The statistics are though not very good for their children. Statisically the couple have a chance of having a normal son, a daughter that is a carrier for hemophilia, a daughter with hemophilia and a son with hemophia.
Her father has to have hemophilia as well, and the mother is a carrier or also has hemophilia. So if we pretend that the hemophilia gene is "x", you need to have "xx" to have hemophilia. The father must have the genotype "Yx" and the mother has the have "Xx" or "xx".
A corrected human hemophilia gene would be considered medicine, as it is aimed at treating a genetic disorder in humans.
Hemophilia is most often caused by mutations in the F8 gene, located on the X chromosome. This gene provides instructions for making a protein called factor VIII, which is essential for blood clotting. Mutations in the F8 gene can result in reduced or absent levels of factor VIII, leading to the characteristic bleeding problems seen in hemophilia.
Because hemophilia is a disease linked to a recessive gene on the X-chromosome, females have another X-chromosome to block out the diseased one. However, males have only one X-chromosome, so they are more often subject to hemophilia.
Queen Victoria had four sons Albert Edward Arthur Alfred Leopold The reason why Albert Edward, Arthur and Alfred did not display hemophilia is because they did not have it. Hemophilia is a sex linked gene. Leopold got hemophilia because Victoria carried the gene. She had one healthy X chromosome and an X that had the gene for hemophilia. Leopold got the X with hemophilia and the other boys got the healthy X chromosome
Because the gene that causes hemophilia is located on the X chromosome, so it will occur in males more frequently than in females.
There are no hard answers to this, it depends strictly on luck. The statistics are though not very good for their children. Statisically the couple have a chance of having a normal son, a daughter that is a carrier for hemophilia, a daughter with hemophilia and a son with hemophia.
The gene that causes hemophilia is located on the X chromosome. A woman who gives birth to a child with hemophilia often has other male relatives who have hemophilia. Sometimes, a baby will be born with hemophilia when there is no known family history. This means the gene can be"hidden"( or passed down through several generations of female carriers without affecting any male members of the family) or the change in the X chromosome is new (a spontaneous mutation).
Gene replacement therapy
Grand Duchess ANASTASIA and her sisters were probably carriers of the hemophilia gene but did not suffer from the effects of hemophilia. Males suffer from hemophilia. In rare cases girls do suffer but that is only when both parents carry the mutated gene
A woman carrying a gene for hemophilia is typically a carrier with one X chromosome carrying the hemophilia gene and one X chromosome carrying the normal gene. When she is mated with a normal male who has one X chromosome and one Y chromosome, there is a 50% chance that the son will inherit the X chromosome carrying the hemophilia gene from the mother. Since males have only one X chromosome, if they inherit the hemophilia gene, they will express the disorder.
Her father has to have hemophilia as well, and the mother is a carrier or also has hemophilia. So if we pretend that the hemophilia gene is "x", you need to have "xx" to have hemophilia. The father must have the genotype "Yx" and the mother has the have "Xx" or "xx".
Yes, hemophilia is typically more common in males than in females. This is because the gene for hemophilia is located on the X chromosome, and males only have one X chromosome. In females, who have two X chromosomes, one healthy gene can compensate for the faulty gene, reducing the chances of exhibiting symptoms.
A corrected human hemophilia gene would be considered medicine, as it is aimed at treating a genetic disorder in humans.
Genetic diseases, such as hemophilia.
It is possible to diagnose Hemophilia in the fetus during pregnancy by demonstrating the abnormal gene.