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An oncogene is?
An oncogene is a gene that has the potential to cause cancer. They can promote cell growth or prevent normal cell death, leading to uncontrolled cell division and tumor formation. Mutations in oncogenes can contribute to the development of cancer.
How can a proto oncogene be converted into an oncogene without a change or mutation in its coding sequence?
It could happen in three main manners: 1) the formation of multiple copies of the gene (duplications) that increase the expression of the gene 2) the mutation happens in the promoter of the gene or in others non coding regions causing an increase in the level of the mRNA of the gene 3) it could happen a translocation that put the gene under an active promoter (bcl2 in lymphomas) , or brings to the formation of a chimaeric gene (the philadelphia chromosome in leukemia)
What are three genetic changes that can convert proto-oncogenes to oncogenes?
Point mutations: Single nucleotide changes can lead to constitutive activation of proto-oncogenes. Gene amplification: Duplication of proto-oncogene sequences can increase gene expression levels, leading to oncogenic transformation. Chromosomal translocations: Rearrangements can cause fusion of a proto-oncogene with a new promoter region, resulting in abnormal activation.
What enzyme is referred to as Akt?
Akt is the enzyme which is known as protein kinase B. Its scientific term is thymoma viral proto-oncogene and its particular job is to help promote cellular revival.
What is the function of the KRAS gene?
The K-ras (perhaps sometimes called the KRAS) gene is an oncogene which activates mutations that will play a key role in diseases such as lung, colorectal, and pancreatic cancer.
How does a protooncogene converted into an oncogene?
A proto-oncogene is normally converted to an oncogene by mutation of the gene that encodes the proto-oncogene. Often, this leads to de-regulation of the proto-oncogenes activity and typically abarrent signal transduction in the cell, which may lead to cellular transformation.
Difference between sarcomas lymphomas carcinomas and leukemia?
Sarcoma virus: contains 'oncogene' Leukaemia virus: Activate human protooncogene via LTR action
Is BRCA1 considered an oncogene?
Yes, BRCA1 is considered a tumor suppressor gene, not an oncogene.
When was Oncogene - journal - created?
Oncogene was first published as a journal in 1987. It covers research related to oncogenes, tumor suppressor genes, and cancer cell biology.
What is pro- oncogene?
An oncogene is a gene, when mutated or expressed at high levels it helps turn a normal cell into a tumor cell.
What is the term for a cancer gene?
Oncogene.
A mutant of a regulatory gene that causes cancer?
oncogene
Which and how many genes are responsible for the thyroid cancer?
RET protooncogene mutation which encodes a transmembrane receptor with tyrosine kinase activity has been linked to PTC and activating mutation of BRAF Activating point mutations in the RAS oncogene has been found in patients with follicular adenoma and carcinoma and p53 mutation and PAX8-peroxisome proliferator-activated receptor gamma [PPAR γ1] and PIK3CA mutations and amplifications and PTEN mutations in the PI3K/Akt signaling pathway and beta-catenin mutations
What gene cause cancer when present in a single copy in a cell?
oncogene
A gene having the potential to trigger cancerous changes in a cell?
oncogene
What process is the protein product of the Ras proto oncogene involved in?
you will have to be more specific There is a point mutation in the k-ras oncogene, and about 60% have a mutation in the p53 so you can develop cancer in the colon by many polyps.
What is proto-oncogen?
A proto-oncogene is a gene that plays a role in normal cell growth and division. When mutated or activated, it can become an oncogene, promoting uncontrolled cell growth and potentially leading to cancer. Examples include growth factor receptors and signaling molecules.
