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Besides fibrous proteins, that have only one type of secondary structure, globular proteins, including enzymes, transport and structural proteins, some peptide hormones, and immunoglobulins, are folded structures much more compact than alpha (helices) or beta (sheets) conformations.


Moreover, globular proteins, with random or repetitive conformations, have roughly spherical shapes. Globular proteins usually exhibit little or no change untill a point is reached at which there is a sudden drastic change and, invariably, a loss of biological function (e.g., structural proteins) or their enzymatic activity (for enzymes), a phenomenon known as denaturation.


Finally, to understand the terciary structure of globular proteins there are two powerful techniques to do it: X-ray or neutron diffraction analysis of single crystals, and NMR analysis (Nuclear Magnetic Resonance) of small proteins in solution.

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Related Questions

Examples of globular functional proteins?

Enzymes


Are most enzymes globular proteins?

yes


What molecules serves as enzymes?

Globular proteins


What type of macromolecules are enzymes made from?

They are made up of proteins. They are globular proteins


What macromolecules are enzymes typically mafe of?

They are protein type. They are globular 3d proteins


What type of organic moleules are most enzymes?

They are type of proteins. They are globular proteins


What kind of molecule is a enzyme?

Many enzymes consist of a protein and a non-protein (called the cofactor). The proteins in enzymes are usually globular. This is the tertiary structure of a protein. These globular proteins include enzymes and immunoglobins. The structures are held in place by hydrogen bonds, disulfide bridges and ionic bonds.


What proteins are in globular proteins?

There are two class of protein based on their structure namely fibrous and globular. Globular proteins form a globe like spherical structure in contrary to rod like fibrous proteins (collagen). They are soluble in water and the structure is rendered by its three dimensional arrangement of amino acids in solution. Most of the enzymes, soluble hormones and factors fall into this class of proteins.


What are enzymes and what makes them up?

Globular proteins which catalize bio chemical reactions are called proteins.


Why enzymes are globular in nature?

Enzymes are globular in nature due to their specific three-dimensional folding, which is essential for their functional activity. This folding is driven by various interactions among amino acids, including hydrogen bonds, hydrophobic interactions, and ionic bonds. The compact, spherical shape allows enzymes to efficiently interact with substrates and catalyze biochemical reactions, ensuring that active sites are properly oriented for optimal binding. Additionally, the globular structure enables enzymes to remain soluble in cellular environments.


Globular protein example?

Hemoglobin, Enzymes, Antibodies, Transporters in Membranes, Some Hormones (e.g. Insulin)


What is the relationship of genes and enzymes?

The link is that a metabolism is made up of different reactions and these reactions have to be catalyzed by enzymes, because without these enzymes most of the reactions in the metabolism wouldn't proceed.