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One molecule of glucose can make either 30 or 32 molecules of ATP, depending on its passage through the cellular respiration pathways.

Glycolysis will yield either 3 or 5 ATP:

2 ATP are formed directly, and then either 1 or 3 can result from the electron carrier NADH (the other energetic product of glycolysis), depending on which shunt the NADH uses to enter the mitochondrion to feed into the electron transport chain (ETC).

If NADH enters via the more-common malate-aspartate shunt, it will generate 3 ATP total.

If it enters via the less-efficient glycerol-3-phosphate shunt (sometimes used by skeletal muscle or by the brain), it will generate only 1 ATP total.

Thus, either 3 or 5 ATP can result from glycolysis.

Pyruvate oxidation will yield 5 ATP:

2 NADH are formed per glucose (because glucose is broken down to 2 pyruvate molecules during glycolysis), each yielding about 2.5 ATP.

Acetyl-CoA oxidation in the TCA cycle will yield 20 ATP:

6 NADH are formed, yielding about 15 ATP; 2 FADH2 are formed, yielding about 3 ATP; and 2 ATP (or GTP) are formed directly, for a total of 20 ATP.

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