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That depends on the isotope! Choose an isotope, count the total number of protons + neutrons, and multiply the result by 3, since both protons and neutrons have 3 quarks each. Note: in the case of helium, the number of protons is 2 in each case, but the number of neutrons can vary, depending on the isotope. The most common isotope has 2 neutrons, but there are other isotopes as well.

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